De novo peptide design

Engineering the molecules of skin longevity.

Novel, patent-protected peptides that target the root molecular drivers of skin aging — designed, not discovered.

Calabi-Yau manifold — Biologic AI mark

The pipeline

Not one molecule — a pipeline.

Cosmetic actives, drug assets and dual-track candidates, spanning the defined drivers of skin aging — every one a novel, patent-filed asset from the same engine.

The platform is the product

Each new target we point the engine at adds another patent-filed program. The pipeline isn't fixed — it compounds as the platform runs.

The pipeline today · cosmetic · drug · dual-track

01Cosmetic
KEAP1 inhibitor
Switches on skin's own antioxidant defense (NRF2)
02Cosmetic
14-3-3σ / stratifin modulator
Blocks a signal that degrades collagen (MMP-1)
03Cosmetic
Copper (ATCUN/GHK)
Collagen-boosting copper, released only in aged skin
04Cosmetic
Methylglyoxal scavenger
Traps the sugars that stiffen & yellow collagen
05Cosmetic
Radical-Scavenger
Antioxidant peptides hardened against self-oxidation
06Cosmetic
Multi-active
Multi-active with designed synergy
07Cosmetic
MMP-12 inhibitor
Stops an enzyme that destroys elastin
08Drug
BCL-xL senolytic
Selectively clears senescent skin cells
09Dual
KLK5 inhibitor
Calms reactive skin by reining in barrier-degrading KLK5
10Cosmetic
Cathepsin K inhibitor
Preserves elasticity by blocking a collagen/elastin-degrading protease

The thesis

We treat skin-aging proteins like drug targets — and design the molecules that hit them.

Every program

novel & patent-filed

Three tracks

cosmetic, drug & dual

One reusable engine

The same oncology-grade, structure-based AI — calibrated on intractable cancer targets, now turned on skin. A platform that produces novel, patentable peptides.

The problem

Skin aging is molecular. Most skincare isn't designed for it.

Aging is driven by defined biology — yet the multi-billion-dollar "actives" market still leans on a handful of decades-old molecules. New, mechanism-specific actives are rare because discovery is slow, empirical, and expensive.

Defined drivers of skin aging

  • 01Glycation — sugar-damaged, stiffened collagen
  • 02Oxidative stress & free-radical damage
  • 03Collapse of the skin's own antioxidant defense
  • 04Elastin breakdown — loss of firmness
  • 05Cellular senescence / inflammaging

Today's actives

Retinoids · Vitamin C · Niacinamide · GHK-Cu copper peptides · Matrixyl · Carnosine — old molecules, broad and indirect.


The opportunity

Treat skin-aging proteins like drug targets and design precise modulators — fast, novel, and ownable.

The platform

An oncology-grade discovery engine.

Every candidate runs a gauntlet of validation — from target to filed IP, end-to-end in silico, before any lab spend. Powered by an orchestrated stack of 50+ computational tools, calibrated against experimental ground truth.

How the engine works

Novel by construction

De novo design yields new, patentable chemical matter — not tweaks of generic actives.

De-risked selection

Consensus scoring and honest gates filter weak designs early — built to reject, not flatter.

Capital-efficient

IP is locked before the lab bill — the cheapest possible way to create defensible value.

Where it was proven

Validated where it's hardest: cancer therapeutics.

The engine was built and calibrated on intractable oncology targets — including RAS isoforms (KRAS / HRAS / NRAS). The methodology is proven on the hardest problems in drug discovery; skin is a more tractable application of the same engine.

Affinity-ranking correlation

ρ ≈ 0.86–0.95

Predicted vs. measured binding, on known-answer sets.

Binder-vs-decoy separation

ROC-AUC 0.92–1.00

True binders cleanly separated from decoys.

Why it's defensible

Novel, owned, and mechanism-specific.

New chemical matter

Patent-protected molecules the incumbents don't own — distinct from the generic, off-patent actives the market relies on.

10 patents filed

Ten U.S. provisional applications filed across the portfolio — composition-of-matter and methods of use.

A compounding moat

Platform + growing IP portfolio + the calibration know-how behind the gates. Each program extends the asset.

The vision

A new category: skin longevity, designed at the molecular level.

Proprietary science can create a new beauty category. We do it with computational discovery instead of lab-first screening — a pipeline of mechanism-specific, patent-protected actives, ready to license or build into an owned, science-first brand.

Get in touch

Partner with us, or request an investor intro.